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. 2016 Jul;51(7):906-12.
doi: 10.1038/bmt.2016.130. Epub 2016 May 16.

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

M Mohty  1 , F Malard  1 , M Abecassis  2 , E Aerts  3 , A S Alaskar  4 , M Aljurf  5 , M Arat  6 , P Bader  7 , F Baron  8 , A Bazarbachi  9 , D Blaise  10 , F Ciceri  11 , S Corbacioglu  12 , J-H Dalle  13 , F Dignan  14 , T Fukuda  15 , A Huynh  16 , T Masszi  17 , M Michallet  18 , A Nagler  19 , M NiChonghaile  20 , S Okamoto  21 , A Pagliuca  22 , C Peters  23 , F B Petersen  24 , P G Richardson  25 , T Ruutu  26 , B N Savani  27 , E Wallhult  28 , I Yakoub-Agha  29 , R F Duarte  30 , E Carreras  31
Affiliations

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

M Mohty et al. Bone Marrow Transplant. 2016 Jul.

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

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Conflict of interest statement

All authors received honoraria and/or research support from JAZZ Pharmaceuticals whose product is discussed in this manuscript. JAZZ pharmaceuticals provided an unrestricted educational grant for support for the current study, but did not participate to the discussions, conduct of the work, data/results analyses or manuscript writing or reviewing. All authors designed the manuscript, analyzed the literature, wrote and commented on the manuscript. All authors approved submission of the manuscript for publication purposes.

References

    1. Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M et al. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 2015; 50: 781–789. - PMC - PubMed
    1. Carreras E, Diaz-Ricart M. The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant 2011; 46: 1495–1502. - PubMed
    1. McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 1984; 4: 116–122. - PubMed
    1. Jones RJ, Lee KS, Beschorner WE, Vogel VG, Grochow LB, Braine HG et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation 1987; 44: 778–783. - PubMed
    1. Coppell JA, Richardson PG, Soiffer R, Martin PL, Kernan NA, Chen A et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant 2010; 16: 157–168. - PMC - PubMed

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