Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jan/Feb;38(1):e469-e481.
doi: 10.1097/BCR.0000000000000355.

Burns: Pathophysiology of Systemic Complications and Current Management

Colton B Nielson  1 , Nicholas C Duethman, James M Howard, Michael Moncure, John G Wood
Affiliations
Review

Burns: Pathophysiology of Systemic Complications and Current Management

Colton B Nielson et al. J Burn Care Res. 2017 Jan/Feb.

Abstract

As a result of many years of research, the intricate cellular mechanisms of burn injury are slowly becoming clear. Yet, knowledge of these cellular mechanisms and a multitude of resulting studies have often failed to translate into improved clinical treatment for burn injuries. Perhaps the most valuable information to date is the years of clinical experience and observations in the management and treatment of patients, which has contributed to a gradual improvement in reported outcomes of mortality. This review provides a discussion of the cellular mechanisms and pathways involved in burn injury, resultant systemic effects on organ systems, current management and treatment, and potential therapies that we may see implemented in the future.

PubMed Disclaimer

References

    1. Colohan SM. Predicting prognosis in thermal burns with associated inhalational injury: a systematic review of prognostic factors in adult burn victims. J Burn Care Res. 2010;31:529–39. - PubMed
    1. Sheppard NN, Hemington-Gorse S, Shelley OP, Philp B, Dziewulski P. Prognostic scoring systems in burns: a review. Burns. 2011;37:1288–95. - PubMed
    1. Hussain A, Dunn KW. Predicting length of stay in thermal burns: a systematic review of prognostic factors. Burns. 2013;39:1331–40. - PubMed
    1. Bohr S, Patel SJ, Shen K, et al. Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns. Proc Natl Acad Sci U S A. 2013;110:3513–8. - PMC - PubMed
    1. Schwacha MG. Macrophages and post-burn immune dysfunction. Burns. 2003;29:1–14. - PubMed

Publication types