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. 2016 Nov;57(11):2575-83.
doi: 10.1080/10428194.2016.1180689. Epub 2016 May 17.

Encouraging experience in the treatment of nasal type extra-nodal NK/T-cell lymphoma in a non-Asian population

Shunan Qi  1   2 , Joachim Yahalom  1 , Meier Hsu  3 , Monica Chelius  1 , Matthew Lunning  4 , Alison Moskowitz  4 , Steven Horwitz  4
Affiliations

Encouraging experience in the treatment of nasal type extra-nodal NK/T-cell lymphoma in a non-Asian population

Shunan Qi et al. Leuk Lymphoma. 2016 Nov.

Abstract

Extra-nodal NK/T-cell lymphoma, nasal type (EN-NK/TCL-NT), is rare in the Western world. We launched the current single-institutional retrospective study with Institutional Review Board approval to better understand the disease. 43 EN-NK/TCL-NT patients treated from 1996 to 2014 were analyzed, including 10 (23%) Asians and 33 (76%) non-Asians. 19/26 (73%) early-stage patients received short-course chemotherapy followed by radiotherapy. 14/17 (82%) advanced-stage patients received primary chemotherapy. Complete response rate was significantly higher in the modified-SMILE group than the accelerated-CHOP group (80% vs. 30%, p = 0.015). The 2-year overall survival (OS) and progression-free survival (PFS) were 60% and 40%, respectively. Early-stage disease had significantly higher 2-year OS (87% vs. 21%) and PFS (56% vs.18%) than advanced-stage (p < 0.001). Ethnicity had no prognostic difference. EN-NK/TCL-NT in non-Asians shared similar disease characteristics and treatment outcomes with Asians. Most early-stage patients have achieved durable remissions. Management of advanced-stage disease remains challenging, with frequent progression and high mortality.

Keywords: Drug therapy; SMILE; ethnology; extranodal NK-T-cell lymphomas; radiotherapy.

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Conflict of interest statement

Potential Conflicts of Interest

Conflict of interest disclosures: Dr. Shunan Qi, MD, Dr. Joachim Yahalom, MD, Meier Hsu, MS, Monica Chelius, BS, Dr. Matthew Lunning, MD, and Dr. Alison Moskowitz, MD, have nothing to disclose. Dr. Steven Horwitz, MD, reports grants and other from Celgene, other from Bristol-Myers Squibb, grants and other from Millennium, other from Amgen, grants and other from Seattle Genetics, grants and other from Spectrum, grants from Infinity, grants from Kiowa-Kirin, outside the submitted work.

Figures

Figure 1
Figure 1
Overall survival and Progression-free survival for this cohort. (Magnification 1x)
Figure 2
Figure 2
Overall survival and progression-free survival by stage. Early stage patients had a significantly better overall survival and progression free survival than advanced stage patients. (Magnification 1x)
See this image and copyright information in PMC

Comment in

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