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Case Reports
. 1989 Mar;23(3):235-6.
doi: 10.1177/106002808902300308.

Phenytoin-carbamazepine cross-sensitivity

S B Reents  1 , W E Luginbuhl, S M Davis
Affiliations
Case Reports

Phenytoin-carbamazepine cross-sensitivity

S B Reents et al. DICP. 1989 Mar.

Abstract

A case of phenytoin-carbamazepine cross-sensitivity is presented. Similar signs and symptoms occurred during administration of both drugs. A common metabolic intermediate is offered as a possible explanation of the mechanism. Clinicians should be careful when choosing alternatives in patients with hypersensitivity reactions to anticonvulsants. Valproic acid may be the safest choice in this setting.

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