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Review
. 2016 Aug 27;33(8):925-32.
doi: 10.1039/c6np00018e. Epub 2016 May 17.

Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle

Pablo Carbonell  1 , Andrew Currin, Adrian J Jervis, Nicholas J W Rattray, Neil Swainston, Cunyu Yan, Eriko Takano, Rainer Breitling
Affiliations
Review

Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle

Pablo Carbonell et al. Nat Prod Rep. .

Abstract

Covering: 2000 to 2016Progress in synthetic biology is enabled by powerful bioinformatics tools allowing the integration of the design, build and test stages of the biological engineering cycle. In this review we illustrate how this integration can be achieved, with a particular focus on natural products discovery and production. Bioinformatics tools for the DESIGN and BUILD stages include tools for the selection, synthesis, assembly and optimization of parts (enzymes and regulatory elements), devices (pathways) and systems (chassis). TEST tools include those for screening, identification and quantification of metabolites for rapid prototyping. The main advantages and limitations of these tools as well as their interoperability capabilities are highlighted.

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Figures

Fig. 1
Fig. 1. Selected bioinformatics tools and associated tasks for the Design/Build/Test cycle in synthetic biology.
None
Pablo Carbonell, Andrew Currin, Adrian Jervis, Nicholas J. W. Rattray, Neil Swainston, Cunyu Yan, Eriko Takano and Rainer Breitling
See this image and copyright information in PMC

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