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. 2016 May-Jun;21(3):322-30.
doi: 10.4103/1735-9066.180389.

The effect of nitric oxide releasing cream on healing pressure ulcers

Affiliations

The effect of nitric oxide releasing cream on healing pressure ulcers

Vahid Saidkhani et al. Iran J Nurs Midwifery Res. 2016 May-Jun.

Abstract

Background: Pressure ulcer is one of the main concerns of nurses in medical centers around the world, which, if untreated, causes irreparable problems for patients. In recent years, nitric oxide (NO) has been proposed as an effective method for wound healing. This study was conducted to determine the effect of nitric oxide on pressure ulcer healing.

Materials and methods: In this clinical trial, 58 patients with pressure ulcer at hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences were homogenized and later divided randomly into two groups of treatment (nitric oxide cream; n = 29) and control (placebo cream; n = 29). In this research, the data collection tool was the Pressure Ulcer Scale for Healing (PUSH). At the outset of the study (before using the cream), the patients' ulcers were examined weekly in terms of size, amount of exudates, and tissue type using the PUSH tool for 3 weeks. By integrating these three factors, wound healing was determined. Data were analyzed using SPSS.

Results: Although no significant difference was found in terms of the mean of score size, the amount of exudates, and the tissue type between the two groups, the mean of total score (healing) between the two groups was statistically significant (P = 0.04).

Conclusions: Nitric oxide cream seems to accelerate wound healing. Therefore, considering its easy availability and cost-effectiveness, it can be used for treating pressure ulcers in the future.

Keywords: Cream; healing; nitric oxide; pressure ulcer; wound healing.

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Figures

Figure 1
Figure 1
Comparison of mean scores of area (size) of the ulcer between the two groups
Figure 2
Figure 2
Comparison of mean scores of tissue type of ulcers between the two groups
Figure 3
Figure 3
Comparison of mean scores of exudates amount between the two groups
Figure 4
Figure 4
Comparison of mean total scores between the two groups

References

    1. Serpa LF, de Gouveia Santos VL, Gomboski G, Rosado SM. Predictive validity of Waterlow Scale for pressure ulcer development risk in hospitalized patients. J Wound Ostomy Continence Nurs. 2009;36:640–6. - PubMed
    1. Berton B. The Management and Prevention of Pressure Sore. 4th ed. Londan: Faber and Faber; 2001. pp. 16–21.
    1. Potter PA. Fundamental of Nursing, Concept, Process and Practice. 3rd ed. St Louis: Mosby; 2007. pp. 50–7.
    1. Paul J, Caroline E. Wound Care Practice. 2nd ed. Palm: Best Publishing Company; 2008. pp. 157–66.
    1. Kaitani T, Tokunaga K, Matsui N, Sanada H. Risk factors related to the development of pressure ulcers in the critical care setting. J Clin Nurs. 2010;19:414–21. - PubMed