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. 2016:24:67-9.
doi: 10.1016/j.ijscr.2016.04.053. Epub 2016 May 6.

Youngest case of ductal carcinoma in situ arising within a benign phyllodes tumour: A case report

Sharat Chopra  1 , Vummiti Muralikrishnan  2 , Maurizio Brotto  3
Affiliations

Youngest case of ductal carcinoma in situ arising within a benign phyllodes tumour: A case report

Sharat Chopra et al. Int J Surg Case Rep. 2016.

Abstract

Introduction: Phyllodes tumour (PT) is a rare tumour of the female breast. The tumour clinically and radiologically mimics the features of a fibroadenoma. Ductal carcinoma in situ (DCIS) in the epithelial component of PT is a very rare finding.

Presentation of case: We present youngest ever case of a 23-year-old nulliparous woman with high-grade ductal carcinoma in situ arising within a benign phyllodes tumor. Macroscopically, it is a homogeneous tumour with solid components. Microscopically, it features typical leaf-like pattern with hypercellular stroma with high-grade ductal carcinoma in situ.

Discussion: To date, eight such rare cases of benign phyllodes tumour with ductal carcinoma in situ have been documented. We report the youngest case known in literature so far.

Conclusion: As this is a very rare presentation, it poses several challenges in regard to both management and follow-up.

Keywords: Benign; Ductal carcinoma in situ; Phyllodes tumour; Young age.

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Figures

Fig. 1
Fig. 1
H&E staining showing hypercellular stroma with absence of atypia or mitosis.
Fig. 2
Fig. 2
H&E staining showing leaf-like structure in a monomorphic background.
Fig. 3
Fig. 3
H&E. staining showing DCIS with comedo necrosis.
See this image and copyright information in PMC

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