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. 2016 Aug 19;81(16):7001-7.
doi: 10.1021/acs.joc.6b00234. Epub 2016 May 23.

Visible Light Induced Oxydifluoromethylation of Styrenes with Difluoromethyltriphenylphosphonium Bromide

Yang Ran  1 , Qing-Yu Lin  1 , Xiu-Hua Xu  1 , Feng-Ling Qing  1   2
Affiliations

Visible Light Induced Oxydifluoromethylation of Styrenes with Difluoromethyltriphenylphosphonium Bromide

Yang Ran et al. J Org Chem. .

Abstract

A convenient, visible light induced oxidifluoromethylation of styrenes was developed. This protocol employs the readily prepared difluoromethyltriphenylphosphonium bromide as the difluoromethylating reagent and alcohols/water as the nucleophiles, affording difluoromethyl(CF2H)-containing alcohols and ethers in moderate to excellent yields.

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