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Case Reports
. 2016 Apr 12;4(5):505-8.
doi: 10.1002/ccr3.516. eCollection 2016 May.

Case report: false positive elevated serum-galactomannan levels after autologous hematopoietic stem cell transplantation caused by oral nutritional supplements

Tobias Rachow  1 , Sebastian Dornaus  1 , Herbert G Sayer  1 , Beate Hermann  2 , Andreas Hochhaus  3 , Marie von Lilienfeld-Toal  4
Affiliations
Case Reports

Case report: false positive elevated serum-galactomannan levels after autologous hematopoietic stem cell transplantation caused by oral nutritional supplements

Tobias Rachow et al. Clin Case Rep. .

Abstract

Positive galactomannan tests in patients who underwent chemotherapy without any clinical signs of a fungal infection should lead the clinician to consideration of a false-positive test result. Oral nutritional supplements may be a cause, especially in the case of concomitant disturbance of the gastrointestinal mucosal barrier because of mucositis.

Keywords: Autologous stem cell transplantation; enteral nutrition; galactomannan; invasive fungal infection.

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Figures

Figure 1
Figure 1
Trends of C‐reactive protein (triangle‐symbols and solid line) and serum‐galactomannan (dots and broken line) after stem cell retransfusion: the C‐reactive protein levels increased with fever in neutropenia and normalized after initiation of an effective antibacterial therapy; the level of serum‐galactomannan increased even after neutropenic reconstitution (on day 12) and fell after advising the patient to quit consuming the hypercaloric drinks.
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