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. 2016 May 17:16:212.
doi: 10.1186/s12879-016-1555-6.

Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia

Zhengrong Chen  1 , Xin Zhao  2 , Xinxing Zhang  1 , Guangbo Zhang  3 , Huiming Sun  1 , Wujun Jiang  1 , Yuqing Wang  1 , Canhong Zhu  1 , Wei Ji  4 , Yongdong Yan  5
Affiliations

Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia

Zhengrong Chen et al. BMC Infect Dis. .

Abstract

Background: The purpose of this study is to explore the correlations of interleukin 36 (IL-36) and Soluble B7-H3 (sB7-H3) levels in bronchoalveolar lavage fluid (BALF) with clinical characteristics and laboratory findings.

Methods: A total of 35 children with M. pneumnoiae pneumonia (MPP) and 15 control subjects were enrolled. BALF concentrations of sB7-H3 and IL-36 were detected using enzyme-linked immunosorbent assays and clinical profiles of children with MPP were obtained.

Results: Children with MPP had significantly higher levels of sB7-H3 and IL-36 compared to control subjects (both P < 0.05). Meanwhile, children with pleural effusion had significantly higher levels of sB7-H3 and IL-36 compared to children without pleural effusion (both P < 0.05). BALF concentration of sB7-H3 was strongly associated with concentration of IL-36 (r = 0.796, P < 0.0001) and sB7-H3 was correlated with duration of fever (r = 0.427, P = 0.11) and length of stay (r = 0.345, P = 0.043). Both concentrations of sB7-H3 and IL-36 were significantly decreased in convalescent phase after treatment (both P < 0.05).

Conclusion: Both soluble B7-H3 and IL-36 may play an important role in pathogenesis of M. pneumoniae infection and sB7-H3 could be useful as a prognostic predictor or biomarker of MPP.

Keywords: B7-H3; Bronchoalveolar lavage fluid; Children; Interleukin 36; Mycoplasma pneumoniae pneumonia.

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Figures

Fig. 1
Fig. 1
Comparison of BALF concentration of sB7-H3 (a) and IL-36 (b) between children with MPP and control subjects as well as comparison of sB7-H3 (c) and IL-36 (d) between children with and without pleural effusion
Fig. 2
Fig. 2
Correlation between BALF concentration of sB7-H3 and IL-36
Fig. 3
Fig. 3
BALF concentrations of sB7-H3 and IL-36 in children with MPP before and after treatment
See this image and copyright information in PMC

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