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Case Reports
. 2016 May 17:2016:bcr2016215881.
doi: 10.1136/bcr-2016-215881.

Cardiac metastatic melanoma

Jay Ramchand  1 , Geoffrey R Wong  2 , Matias B Yudi  1 , Stephen Sylivris  1
Affiliations
Case Reports

Cardiac metastatic melanoma

Jay Ramchand et al. BMJ Case Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Fluorodeoxyglucose (FDG) positron emission tomography. A focal area of FDG uptake which in the high anterior wall of the left ventricle is not typical of normal ventricular wall uptake (black arrow). Prominent bowel uptake of FDG was consistent with oral metformin therapy.
Figure 2
Figure 2
Transoesophageal echocardiogram. Mid-oesophageal two-chamber view. There is a large mobile mass (4.5×2.5 cm) within the left ventricular cavity attached to the anterior wall (white arrow). It is broad-based, multilobed and has a variegated appearance. LA, left atrium; LV, left ventricle.
Figure 3
Figure 3
Cardiac MRI. Two-chamber view. A large voluminous, mobile mass is demonstrated within the left ventricular cavity (white arrow).
Figure 4
Figure 4
Cardiac MRI. Two-chamber view. Late gadolinium contrast-enhanced sequence. Left ventricular metastatic melanoma (black arrow). No evidence of macroscopic infiltration of the anterior myocardium.
Figure 5
Figure 5
H&E stained histology section of resected left ventricular mass. Section demonstrates sheets of dyscohesive, malignant epithelioid cells with prominent nucleoli and frequent mitoses (black arrow) consistent with metastatic melanoma. There was strong expression of S100 in the malignant cells.
See this image and copyright information in PMC

References

    1. Glancy DL, Roberts WC. The heart in malignant melanoma. A study of 70 autopsy cases. Am J Cardiol 1968;21:555–71. doi:10.1016/0002-9149(68)90289-0 - DOI - PubMed
    1. Gibbs P, Cebon JS, Calafiore P et al. . Cardiac metastases from malignant melanoma. Cancer 1999;85:78–84. - PubMed
    1. Mousseaux E, Meunier P, Azancott S et al. . Cardiac metastatic melanoma investigated by magnetic resonance imaging. Magn Reson Imaging 1998;16:91–5. doi:10.1016/S0730-725X(97)00200-2 - DOI - PubMed

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