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. 2016 May 27;34(5):220-30.
doi: 10.1080/07357907.2016.1183023. Epub 2016 May 18.

Apoptosis-Mediated Chemoprevention by Different Ratios of Fish Oil in Experimental Colon Carcinogenesis

Gayatri Sharma  1 , Isha Rani  1 , Archana Bhatnagar  1 , Navneet Agnihotri  1
Affiliations

Apoptosis-Mediated Chemoprevention by Different Ratios of Fish Oil in Experimental Colon Carcinogenesis

Gayatri Sharma et al. Cancer Invest. .

Abstract

Apoptosis plays an important role in prevention of colon cancer. In the present study, different ratios of fish oil and corn oil increased Fas expression in both phases and a decrease in FasL expression only in post initiation phase. Treatment with fish oil activated the intrinsic apoptotic pathway by increasing Bax expression and Cyt c release and decreasing Bcl-2 levels in both phases. This suggests that intrinsic pathway is upregulated by fish oil; however, Fas-FasL activity may be involved in inhibition of reversal of immune surveillance in tumor cells.

Keywords: Cancer; Fish oil (FO); Polyunsaturated fatty acids (PUFA); n-3 Fatty acids.

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