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Case Reports
. 2016 Apr;91(2):223-5.
doi: 10.1590/abd1806-4841.20163817.

Paronychia and granulation tissue formation during treatment with isotretinoin

Daniela de Almeida Figueiras  1 , Ticiana Batista Ramos  1 , Ayana Karla de Oliveira Ferreira Marinho  1 , Milena Soneley Mendonça Bezerra  1 , Renata Cavalcanti Cauas  1
Affiliations
Case Reports

Paronychia and granulation tissue formation during treatment with isotretinoin

Daniela de Almeida Figueiras et al. An Bras Dermatol. 2016 Apr.

Abstract

This paper describes the association of two unusual side effects of treatment with isotretinoin for severe acne: paronychia and excess granulation tissue in the nails furrows. We report a case of male patient aged 19 years, who in the course of the 36th week of treatment with isotretinoin for acne grade III showed erythema, edema, excess granulation tissue and onychocryptosis in various nail beds of hands and feet, with no history of trauma associated. A literature review revealed few reports of these adverse events, and two clinical patterns of exuberant granulation tissue has been described: one in periungual location and other in lesions of previous acne. The rarity and lack of knowledge on the best treatment for granuloma-like reactions make this theme a considerable challenge.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Figure 1
Figure 1
Paronychia and granulation tissue in feet, secondary to the use of isotretinoin
Figure 2
Figure 2
Pyogenic-like granuloma and paronychia in lateral edge of the first and second right toes
Figure 3
Figure 3
Excess of periungueal granulation tissue and paronychia, located in the first left toe
Figure 4
Figure 4
Two months after the completion of matricectomy: patient presented resolution of onicocriptosis without recurrence of the lesions on toes
See this image and copyright information in PMC

References

    1. Kanigsberg N, DesGroseilliers JP. Use of 13-cis-retinoic acid in cystic acne. Can Med Assoc J. 1983;129:224–224. 228–228. - PMC - PubMed
    1. Exner JH, Dahod S, Pochi PE. Pyogenic granuloma-like acne lesions during isotretinoin therapy. Arch Dermatol. 1983;119:808–811. - PubMed
    1. Brelsford M, Beute TC. Preventing and managing the side effects of isotretinoin. Semin Cutan Med Surg. 2008;27:197–206. - PubMed
    1. Charakida A, Mouser PE, Chu AC. Safety and side effects of the acne drug, oral isotretinoin. Expert Opin Drug Saf. 2004;3:119–129. - PubMed
    1. Bigby M, Stern RS. Adverse reactions to isotretinoin. A report from the Adverse Drug Reaction Reporting System. J Am Acad Dermatol. 1988;18:543–552. - PubMed

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