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. 2016 Jun;22(6):1113-1115.
doi: 10.3201/eid2206.160010.

Antibody Response and Disease Severity in Healthcare Worker MERS Survivors

Abeer N Alshukairi, Imran Khalid, Waleed A Ahmed, Ashraf M Dada, Daniyah T Bayumi, Laut S Malic, Sahar Althawadi, Kim Ignacio, Hanadi S Alsalmi, Hail M Al-Abdely, Ghassan Y Wali, Ismael A Qushmaq, Basem M Alraddadi, Stanley Perlman

Antibody Response and Disease Severity in Healthcare Worker MERS Survivors

Abeer N Alshukairi et al. Emerg Infect Dis. 2016 Jun.

Abstract

We studied antibody response in 9 healthcare workers in Jeddah, Saudi Arabia, who survived Middle East respiratory syndrome, by using serial ELISA and indirect immunofluorescence assay testing. Among patients who had experienced severe pneumonia, antibody was detected for >18 months after infection. Antibody longevity was more variable in patients who had experienced milder disease.

Keywords: ELISA; IFA; Jeddah; MERS-CoV; Middle East respiratory syndrome coronavirus; Saudi Arabia; antibody; healthcare workers; immune response; indirect immunofluorescence assay; viruses.

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References

    1. Liu W, Fontanet A, Zhang PH, Zhan L, Xin ZT, Baril L, et al. Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome. J Infect Dis. 2006;193:792–5 . 10.1086/500469 - DOI - PMC - PubMed
    1. Tang F, Quan Y, Xin ZT, Wrammert J, Ma MJ, Lv H, et al. Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study. J Immunol. 2011;186:7264–8. 10.4049/jimmunol.0903490 - DOI - PubMed
    1. Corman VM, Albarrak AM, Omrani AS, Albarrak MM, Farah ME, Almasri M, et al. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clin Infect Dis. 2016;62:477–83 . - PMC - PubMed
    1. Park WB, Perera RA, Choe PG, Lau EH, Choi SJ, Chun JY, et al. Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea. Emerg Infect Dis. 2015;21:2186–9. 10.3201/eid2112.151421 - DOI - PMC - PubMed
    1. Buchholz U, Müller MA, Nitsche A, Sanewski A, Wevering N, Bauer-Balci T, et al. Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October–November 2012. Euro Surveill. 2013;18:20406 . - PubMed

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