Regulatory T Cells: A Crisis Averted

Deepali Malhotra¹, Marc K Jenkins²

Affiliations

¹ Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
² Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: jenki002@umn.edu.

PMID: 27192571
DOI: 10.1016/j.immuni.2016.04.025

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Regulatory T Cells: A Crisis Averted

Deepali Malhotra et al. Immunity. 2016.

Free article

. 2016 May 17;44(5):1079-81.

doi: 10.1016/j.immuni.2016.04.025.

Authors

Deepali Malhotra¹, Marc K Jenkins²

Affiliations

¹ Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
² Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: jenki002@umn.edu.

PMID: 27192571
DOI: 10.1016/j.immuni.2016.04.025

Abstract

Although regulatory T cells protect people from autoimmunity, two recent papers in Immunity (Malchow et al., 2016; Kieback et al., 2016) demonstrate that these cells are also a crisis averted. Without the proper education in the thymus, these cells will turn on their host and cause autoimmunity.

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Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage.
Malchow S, Leventhal DS, Lee V, Nishi S, Socci ND, Savage PA. Malchow S, et al. Immunity. 2016 May 17;44(5):1102-13. doi: 10.1016/j.immuni.2016.02.009. Epub 2016 Apr 26. Immunity. 2016. PMID: 27130899 Free PMC article.
Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity.
Kieback E, Hilgenberg E, Stervbo U, Lampropoulou V, Shen P, Bunse M, Jaimes Y, Boudinot P, Radbruch A, Klemm U, Kühl AA, Liblau R, Hoevelmeyer N, Anderton SM, Uckert W, Fillatreau S. Kieback E, et al. Immunity. 2016 May 17;44(5):1114-26. doi: 10.1016/j.immuni.2016.04.018. Immunity. 2016. PMID: 27192577

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Regulatory T Cells: A Crisis Averted

Affiliations

Regulatory T Cells: A Crisis Averted

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