Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May 18;9(1):46.
doi: 10.1186/s13045-016-0276-z.

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Ke Zhao  1 , Qifa Liu  2
Affiliations
Review

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Ke Zhao et al. J Hematol Oncol. .

Abstract

Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications.

Keywords: Aplastic anemia; Engraftment failure; Graft-versus-host disease; Hematopoietic stem cell transplantation; Infection; Mesenchymal stromal cell; Relapse.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Immunomodulatory effects of MSC. MSCs exert immunomodulatory effects mainly through central and peripheral immune compartments. MSCs modulate central immune compartments by repairing damaged thymus, promoting T-cells maturation, inducing the proliferation of natural Tregs, and differentiating to thymocytes. MSCs modulate peripheral immune compartments, including interacting with various immune cells and secreting various soluble mediators involved in different microenvironment. They suppress T cell and B cell proliferation, induce the generation and proliferation of Tregs and Bregs, inhibit differentiation of precursors into DCs, suppress DCs maturation, and influence the function of NK cells
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9(5):641–50. doi: 10.1002/jor.1100090504. - DOI - PubMed
    1. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1992;13(1):81–8. doi: 10.1016/8756-3282(92)90364-3. - DOI - PubMed
    1. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992;13(1):69–80. doi: 10.1016/8756-3282(92)90363-2. - DOI - PubMed
    1. da Silva ML, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119(11):2204–13. doi: 10.1242/jcs.02932. - DOI - PubMed
    1. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24(5):1294–301. doi: 10.1634/stemcells.2005-0342. - DOI - PubMed

MeSH terms

LinkOut - more resources