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. 2016 May 19:6:26174.
doi: 10.1038/srep26174.

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

Yanyan Chen  1 , Xiafang Wu  2 , Ruirui Wu  2 , Xiance Sun  3 , Boyi Yang  4 , Yi Wang  4 , Yuanyuan Xu  2
Affiliations

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

Yanyan Chen et al. Sci Rep. .

Abstract

Changes in profile of lipids and adipokines have been reported in patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore the relationships between thyroid function and the profile of lipids and adipokines. A cross-sectional study was conducted in 197 newly diagnosed hypothyroid patients, 230 newly diagnosed hyperthyroid patients and 355 control subjects. Hypothyroid patients presented with significantly higher serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), fasting insulin, resistin and leptin than control (p < 0.05). Hyperthyroid patients presented with significantly lower serum levels of high-density lipoprotein cholesterol, LDLC and leptin, as well as higher levels of fasting insulin, resistin, adiponectin and homeostasis model insulin resistance index (HOMA-IR) than control (p < 0.05). Nonlinear regression and multivariable linear regression models all showed significant associations of resistin or adiponectin with free thyroxine and association of leptin with thyroid-stimulating hormone (p < 0.001). Furthermore, significant correlation between resistin and HOMA-IR was observed in the patients (p < 0.001). Thus, thyroid dysfunction affects the profile of lipids and adipokines. Resistin may serve as a link between thyroid dysfunction and insulin resistance.

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Figures

Figure 1
Figure 1. Serum levels of adiponectin, resistin and leptin in control, hypothyroid and hyperthyroid groups.
Data are expressed as box and whiskers (medium and min to max). *p < 0.05 compared with control. #p < 0.05 compared with hypothyroid group.
Figure 2
Figure 2. Associations of serum adipokines with FT4 or TSH analyzed by quadratic regression model.
Plots show the association between serum adiponectin, resistin or leptin and FT4 or TSH as predicted mean with 95% confidence interval.
Figure 3
Figure 3. Correlation between HOMA-IR and serum levels of resistin in control, hypothyroid and hyperthyroid groups.
Partial r was assessed by linear regression model with age, gender, BMI, TC, TG, HDLC and LDLC as independent variables.
See this image and copyright information in PMC

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