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. 2016 May 19;20(1):131.
doi: 10.1186/s13054-016-1308-3.

Muscle regeneration after sepsis

Adrien Bouglé  1   2 , Pierre Rocheteau  3 , Tarek Sharshar  3   4   5   6 , Fabrice Chrétien  3   6   7   8
Affiliations

Muscle regeneration after sepsis

Adrien Bouglé et al. Crit Care. .

Abstract

Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.

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