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. 2016 May 19;533(7603):333-7.
doi: 10.1038/nature17987.

Reproducible pharmacogenomic profiling of cancer cell line panels

Peter M Haverty  1 , Eva Lin  2 , Jenille Tan  2 , Yihong Yu  2 , Billy Lam  2 , Steve Lianoglou  1 , Richard M Neve  2 , Scott Martin  2 , Jeff Settleman  2 , Robert L Yauch  2 , Richard Bourgon  1
Affiliations

Reproducible pharmacogenomic profiling of cancer cell line panels

Peter M Haverty et al. Nature. .

Abstract

The use of large-scale genomic and drug response screening of cancer cell lines depends crucially on the reproducibility of results. Here we consider two previously published screens, plus a later critique of these studies. Using independent data, we show that consistency is achievable, and provide a systematic description of the best laboratory and analysis practices for future studies.

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