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. 2016 Mar;467(1):102-4.
doi: 10.1134/S1607672916020071. Epub 2016 May 20.

The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na(+) transport in frog skin

Z I Krutetskaya  1 , A V Melnitskaya  2 , V G Antonov  2 , A D Nozdrachev  2
Affiliations

The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na(+) transport in frog skin

Z I Krutetskaya et al. Dokl Biochem Biophys. 2016 Mar.

Abstract

Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na(+) transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na(+) transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na(+) transport in frog skin.

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