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. 2016 Mar;467(1):128-31.
doi: 10.1134/S1607672916020149. Epub 2016 May 20.

The oxidative modification of cellular fibrin-stabilizing factor

M A Rosenfeld  1 , A N Shchegolikhin  2 , V B Leonova  2 , E A Kostanova  2 , M I Biryukova  2 , A V Bychkova  2 , M L Konstantinova  2 , A D Vasilyeva  2
Affiliations

The oxidative modification of cellular fibrin-stabilizing factor

M A Rosenfeld et al. Dokl Biochem Biophys. 2016 Mar.

Abstract

For the first time, the induced oxidative modification of cellular fibrin-stabilizing factor (cFXIII) has been studied. According to the electrophoresis analysis, the conversion of oxidized cFXIII into FXIIIa resulted in producing the enzyme that significantly lost the initial enzymatic activity. At the same time, FXIIIa subjected to induced oxidation was completely devoid of enzymatic activity. The results of FTIR spectroscopy showed that the oxidation of cFXIII or FXIIIa was accompanied by profound changes both in chemical and spatial structures of the protein. The results of this study are in good agreement with our earlier assumption regarding the antioxidant role of the regulatory subunits B of plasma fibrin-stabilizing factor.

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References

    1. Biochem Biophys Res Commun. 2015 May 29;461(2):408-12 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Jul;66(3):738-44 - PubMed
    1. Physiol Rev. 2011 Jul;91(3):931-72 - PubMed
    1. Int J Biochem. 1992;24(1):91-7 - PubMed
    1. Biochim Biophys Acta. 2013 Dec;1834(12):2470-9 - PubMed

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