Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Feb;33(2):242-4.
doi: 10.1128/AAC.33.2.242.

Macrolide accumulation by Bacteroides fragilis ATCC 25285

Y Muto  1 , K Bandoh, K Watanabe, N Katoh, K Ueno
Affiliations

Macrolide accumulation by Bacteroides fragilis ATCC 25285

Y Muto et al. Antimicrob Agents Chemother. 1989 Feb.

Abstract

The accumulation of macrolide antibiotics in Bacteroides fragilis ATCC 25285 was increased in the order erythromycin, josamycin, and rokitamycin, depending on hydrophobicity. The half-times of efflux were also prolonged in the same order. Furthermore, MICs of the antibiotics were correlated with the extent of hydrophobicity. These findings suggest that the macrolide antibiotics are accumulated in B. fragilis by means of their hydrophobic properties, and the efficient accumulation of the drugs may explain the susceptibility of this gram-negative bacterium to macrolides.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1984 Jan;25(1):131-3 - PubMed
    1. Annu Rev Microbiol. 1984;38:237-64 - PubMed
    1. Microbiol Rev. 1985 Mar;49(1):1-32 - PubMed
    1. J Bacteriol. 1968 Mar;95(3):1111-7 - PubMed
    1. Biochim Biophys Acta. 1968 Apr 22;157(2):404-13 - PubMed

LinkOut - more resources