Pagetoid Reticulosis: Report of Two Cases and Review of the Literature

Abstract

Pagetoid reticulosis is a rare variant of mycosis fungoides that presents with a large, usually single, erythematous, slowly growing scaly plaque containing an intraepidermal proliferation of neoplastic T lymphocytes. Histopathologically, this disease has distinctive attributes. In this report, we present two cases of pagetoid reticulosis, compare its microscopic features to those of 'classical' mycosis fungoides, and provide a brief review of the pertinent literature.

Keywords: Cutaneous T-cell lymphoma; Mycosis fungoides; Pagetoid reticulosis; Skin tumors; Woringer-Kolopp disease.

Fig. 1

Composite of images from both PR cases showing a dense intraepidermal infiltrate of atypical lymphoid cells, with epidermal acanthosis. There are only a few lesional cells in the upper dermis.

Fig. 2

Immunohistological findings of both PR cases. Diffuse immunoreactivity was present for CD2, CD3, CD4, CD43, and CD45R0, but labeling for CD7 was comparatively diminished. CD8+ lymphocytes were sparse and CD30 was absent.