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. 1977 Dec;74(12):5368-71.
doi: 10.1073/pnas.74.12.5368.

Regulation of proline oxidase activity by lactate

E M Kowaloff, J M Phang, A S Granger, S J Downing

Regulation of proline oxidase activity by lactate

E M Kowaloff et al. Proc Natl Acad Sci U S A. 1977 Dec.

Abstract

We found that proline oxidase, the first enzyme of the proline degradative pathway, is inhibited by lactate. The Km of the enzyme for proline increases with increasing concentrations of lactate. Since proline can be a source for gluconeogenesis, regulation of proline degradation by lactate may serve as a mechanism for allocation of metabolic fuel sources. The marked inhibition of proline oxidase at levels of lactate that commonly occur in both genetic and acquired lactic acidosis may cause the previously unexplained hyperprolinemia seen in these metabolic disorders.

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References

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