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. 2016 Aug:49:196-201.
doi: 10.1016/j.ijid.2016.05.009. Epub 2016 May 16.

Rubella immunity among pregnant women aged 15-44 years, Namibia, 2010

Anna Jonas  1 , Cristina V Cardemil  2 , Anita Beukes  3 , Raydel Anderson  4 , Paul A Rota  4 , Bettina Bankamp  4 , Howard E Gary Jr  5 , Souleymane Sawadogo  3 , Sadhna V Patel  3 , Sikota Zeko  1 , Clementine Muroua  1 , Esegiel Gaeb  6 , Kathleen Wannemuehler  5 , Sue Gerber  3 , James L Goodson  5
Affiliations

Rubella immunity among pregnant women aged 15-44 years, Namibia, 2010

Anna Jonas et al. Int J Infect Dis. 2016 Aug.

Abstract

Background: The level of rubella susceptibility among women of reproductive age in Namibia is unknown. Documenting the risk of rubella will help estimate the potential burden of disease in Namibian women and the risk of congenital rubella syndrome (CRS) in infants, and will guide strategies for the introduction of rubella vaccine.

Methods: A total of 2044 serum samples from pregnant Namibian women aged 15-44 years were tested for rubella immunoglobulin G antibody; the samples were obtained during the 2010 National HIV Sentinel Survey. The proportion of women seropositive for rubella was determined by 5-year age strata, and factors associated with seropositivity were analyzed by logistic regression, including age, gravidity, HIV status, facility type, and urban/rural status.

Results: Overall rubella seroprevalence was 85% (95% confidence interval (CI) 83-86%). Seroprevalence varied by age group (83-90%) and health district (71-100%). In the multivariable model, women from urban residences had higher odds of seropositivity as compared to women from rural residences (odds ratio 1.40, 95% CI 1.09-1.81).

Conclusions: In the absence of a routine rubella immunization program, the high level of rubella seropositivity suggests rubella virus transmission in Namibia, yet 15% of pregnant Namibian women remain susceptible to rubella. The introduction of rubella vaccine will help reduce the risk of rubella in pregnant women and CRS in infants.

Keywords: Namibia; Population immunity; Pregnant women; Rubella; Seroprevalence.

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Conflict of interest statement

Conflict of interest: None.

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References

    1. Centers for Disease Control and Prevention. Rubella and congenital rubella syndrome control and elimination—global progress, 2000–2012. MMWR Morb Mortal Wkly Rep 2013;62:983–6. - PMC - PubMed
    1. Cutts FT, Robertson SE, Diaz-Ortega JL, Samuel R. Control of rubella and congenital rubella syndrome (CRS) in developing countries, Part 1: burden of disease from CRS. Bull World Health Organ 1997;75:55–68. - PMC - PubMed
    1. World Health Organization. Global measles and rubella strategic plan: 2012–2020. Geneva: WHO; 2012. Available at: http://www.who.int/immunization/newsroom/Measles_Rubella_StrategicPlan_2... (accessed March 31, 2016).
    1. Vynnycky E, Adams EJ, Cutts FT, Reef SE, Navar AM, Simons E, et al. Using seroprevalence and immunisation coverage data to estimate the global burden of congenital rubella syndrome, 1996–2010: a systematic review. PLoS One 2016;11:1–20. 10.1371/journal.pone.0149160, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149160 - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention. Progress toward control of rubella and prevention of congenital rubella syndrome—worldwide, 2009. MMWR Morb Mortal Wkly Rep 2010;59:1307–10. - PubMed