IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance

T Imamura^{1

2}, M Yano¹, D Asai¹, A Moriya-Saito³, S-I Suenobu^{2

4}, D Hasegawa^{2

5}, T Deguchi^{2

6}, Y Hashii^{2

7}, H Kawasaki^{2

8}, H Hori^{2

6}, K Yumura-Yagi^{2

9}, J Hara^{2

10}, K Horibe^{2

3}, A Sato^{2

11}

Affiliations

¹ Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
² Japan Association of Childhood Leukemia Study Group (JACLS), Suita, Japan.
³ Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
⁴ Division of General Pediatrics and Emergency Medicine, Department of Pediatrics, Oita University, Oita, Japan.
⁵ Department of Hematology/Oncology, Hyogo Prefectural Children's Hospital, Kobe, Japan.
⁶ Department of Pediatrics, Mie University, Tsu, Japan.
⁷ Department of Pediatrics, Osaka University, Osaka, Japan.
⁸ Department of Pediatrics, Kansai Medical University, Hirakata, Japan.
⁹ Yumura Clinic, Osaka, Japan.
¹⁰ Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan.
¹¹ Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan.

PMID: 27198053
DOI: 10.1038/leu.2016.128

Comment

IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance

T Imamura et al. Leukemia. 2016 Aug.

. 2016 Aug;30(8):1801-3.

doi: 10.1038/leu.2016.128. Epub 2016 May 20.

Authors

Affiliations

¹ Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
² Japan Association of Childhood Leukemia Study Group (JACLS), Suita, Japan.
³ Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
⁴ Division of General Pediatrics and Emergency Medicine, Department of Pediatrics, Oita University, Oita, Japan.
⁵ Department of Hematology/Oncology, Hyogo Prefectural Children's Hospital, Kobe, Japan.
⁶ Department of Pediatrics, Mie University, Tsu, Japan.
⁷ Department of Pediatrics, Osaka University, Osaka, Japan.
⁸ Department of Pediatrics, Kansai Medical University, Hirakata, Japan.
⁹ Yumura Clinic, Osaka, Japan.
¹⁰ Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan.
¹¹ Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan.

PMID: 27198053
DOI: 10.1038/leu.2016.128

No abstract available

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Comment on

Tumor suppressor IKZF1 mediates glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Marke R, Havinga J, Cloos J, Demkes M, Poelmans G, Yuniati L, van Ingen Schenau D, Sonneveld E, Waanders E, Pieters R, Kuiper RP, Hoogerbrugge PM, Kaspers GJ, van Leeuwen FN, Scheijen B. Marke R, et al. Leukemia. 2016 Jul;30(7):1599-603. doi: 10.1038/leu.2015.359. Epub 2015 Dec 29. Leukemia. 2016. PMID: 26713593 No abstract available.

References

1. Cancer Med. 2013 Jun;2(3):412-9 - PubMed
1. Nat Immunol. 2014 Mar;15(3):294-304 - PubMed
1. Nature. 2011 Mar 10;471(7337):235-9 - PubMed
1. PLoS One. 2015 Aug 28;10(8):e0136428 - PubMed
1. Leukemia. 2016 Jul;30(7):1599-603 - PubMed

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IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance

Affiliations

IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance

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Medical