Long lasting respiratory depression induced by morphine-6-glucuronide?
- PMID: 2719905
- PMCID: PMC1379732
- DOI: 10.1111/j.1365-2125.1989.tb05401.x
Long lasting respiratory depression induced by morphine-6-glucuronide?
Abstract
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome. The plasma concentrations of the active metabolite M6G were more than 10 times those normally seen and the half-lives of M6G and morphine were prolonged.
Similar articles
-
Morphine-6-glucuronide: morphine's successor for postoperative pain relief?Anesth Analg. 2006 Jun;102(6):1789-97. doi: 10.1213/01.ane.0000217197.96784.c3. Anesth Analg. 2006. PMID: 16717327 Review.
-
Morphine-6-glucuronide (M6G) for postoperative pain relief.Eur J Pain. 2008 May;12(4):403-11. doi: 10.1016/j.ejpain.2007.07.009. Epub 2007 Sep 14. Eur J Pain. 2008. PMID: 17869146 Review.
-
Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain.Curr Opin Investig Drugs. 2008 Jul;9(7):786-99. Curr Opin Investig Drugs. 2008. PMID: 18600584 Review.
-
A randomised controlled trial on the efficacy and side-effect profile (nausea/vomiting/sedation) of morphine-6-glucuronide versus morphine for post-operative pain relief after major abdominal surgery.Eur J Pain. 2011 Apr;15(4):402-8. doi: 10.1016/j.ejpain.2010.09.007. Epub 2010 Oct 30. Eur J Pain. 2011. PMID: 21041105 Clinical Trial.
-
Efficacy and safety of morphine-6-glucuronide (M6G) for postoperative pain relief: a randomized, double-blind study.Eur J Pain. 2009 Mar;13(3):293-9. doi: 10.1016/j.ejpain.2008.04.015. Epub 2008 Jun 11. Eur J Pain. 2009. PMID: 18550399 Clinical Trial.
Cited by
-
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide.Br J Cancer. 1992 Jan;65(1):122-6. doi: 10.1038/bjc.1992.23. Br J Cancer. 1992. PMID: 1310249 Free PMC article.
-
Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors.Clin Pharmacokinet. 1992 Oct;23(4):292-310. doi: 10.2165/00003088-199223040-00005. Clin Pharmacokinet. 1992. PMID: 1395362 Review.
-
The role of beta-glucuronidase in drug disposition and drug targeting in humans.Clin Pharmacokinet. 1997 Jul;33(1):18-31. doi: 10.2165/00003088-199733010-00003. Clin Pharmacokinet. 1997. PMID: 9250421 Review.
-
Plasma concentrations and renal clearance of morphine, morphine-3-glucuronide and morphine-6-glucuronide in cancer patients receiving morphine.Clin Pharmacokinet. 1993 May;24(5):413-20. doi: 10.2165/00003088-199324050-00005. Clin Pharmacokinet. 1993. PMID: 8504624
-
Morphine-6-glucuronide: an analgesic of the future?Clin Pharmacokinet. 2001;40(7):485-99. doi: 10.2165/00003088-200140070-00001. Clin Pharmacokinet. 2001. PMID: 11510626 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources