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Case Reports
. 2015 Dec;34(2-3):139-40.

Rhabdomyolysis in hyponatremia and paraneoplastic syndrome of inappropriate antidiuresis

Elisabetta D'Adda  1 , Rosina Paletta  1 , Fabio Brusaferri  1 , Antonio Cagnana  1 , Maria Teresa Ferrò  1 , Michele Gennuso  1 , Isabella Ghione  1 , Riccardo Saponara  1 , Alessandro Prelle  1
Affiliations
Case Reports

Rhabdomyolysis in hyponatremia and paraneoplastic syndrome of inappropriate antidiuresis

Elisabetta D'Adda et al. Acta Myol. 2015 Dec.

Abstract

We report a 26-year-old woman admitted to our hospital for generalized tonic seizure. Laboratory investigations revealed severe hyponatremia possibly triggered by vomiting and diarrhea. 24 hours after correction of hyponatremia she developed diffuse myalgias and marked hyperCKemia. Syndrome of inappropriate antidiuresis (SIAD) was suspected as cause of hyponatremia. Abnormal vaginal bleeding prompts gynecological evaluation and a small-cell carcinoma of uterine cervix was detected.

Keywords: hyponatriemia; rhabdomyolisis; small cell neuroendocrine carcinoma; syndrome of inappropriate antidiuresis.

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References

    1. Zaidi AN. Rhabdomyolysis after correction of hyponatremia in psychogenic polydipsia possibly complicated by ziprasidone. Ann Pharmacother. 2005;39:1726–1731. - PubMed
    1. Sterns RH. Disorders of plasma sodium. causes, consequences, and correction. N Engl J Med. 2015;372:55–65. - PubMed
    1. Lara Aguayo P, Fuente Martos C, Morán Fernández E, et al. Rhabdomyolysis secondary to hyponatraemia. Nefrologia. 2011;31:489–502. - PubMed
    1. Trimarchi H, Gonzalez J, Olivero J. Hyponatremia-associated rhabdomyolysis. Nephron. 1999;82:274–277. - PubMed
    1. Esposito P, Piotti G, Bianzina S, et al. The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options. Nephron Clinical Practice. 2011;119:c62–c73. - PubMed

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