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. 1989 May;55(5):987-99.
doi: 10.1016/S0006-3495(89)82897-8.

Current injection into a two-dimensional anisotropic bidomain

N G Sepulveda  1 , B J Roth, J P Wikswo Jr
Affiliations

Current injection into a two-dimensional anisotropic bidomain

N G Sepulveda et al. Biophys J. 1989 May.

Abstract

A two-dimensional sheet of anisotropic cardiac tissue is represented with the bidomain model, and the finite element method is used to solve the bidomain equations. When the anisotropy ratios of the intracellular and extracellular spaces are not equal, the injection of current into the tissue induces a transmembrane potential that has a complicated spatial dependence, including adjacent regions of depolarized and hyperpolarized tissue. This behavior may have important implications for the electrical stimulation of cardiac tissue and for defibrillation.

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