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. 1989 Apr;5(2):151-3.
doi: 10.1093/bioinformatics/5.2.151.

Fast and sensitive multiple sequence alignments on a microcomputer

D G Higgins  1 , P M Sharp
Affiliations

Fast and sensitive multiple sequence alignments on a microcomputer

D G Higgins et al. Comput Appl Biosci. 1989 Apr.

Abstract

A strategy is described for the rapid alignment of many long nucleic acid or protein sequences on a microcomputer. The program described can handle up to 100 sequences of 1200 residues each. The approach is based on progressively aligning sequences according to the branching order in an initial phylogenetic tree. The results obtained using the package appear to be as sensitive as those from any other available method.

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