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Review
. 2016 Sep;175(9):1227-1234.
doi: 10.1007/s00431-016-2733-7. Epub 2016 May 20.

Mono-sensitisation to peanut component Ara h 6: a case series of five children and literature review

J P M van der Valk  1 , M W J Schreurs  2 , R El Bouch  3 , N J T Arends  3   4 , N W de Jong  3
Affiliations
Review

Mono-sensitisation to peanut component Ara h 6: a case series of five children and literature review

J P M van der Valk et al. Eur J Pediatr. 2016 Sep.

Abstract

Here, we summarise the current clinical knowledge on Ara h 6 sensitisation and clinical relevance of this sensitisation pattern using five illustrative clinical cases. The literature search yielded a total of 166 papers, and an additional relevant article was found by 'snowballing'. A total of ten articles were considered relevant for this review. Most studies included patients with a sensitisation to Ara h 6 and cosensitisation to Ara h 2. Only three studies showed patients with a mono-sensitisation to Ara h 6. This illustrates that Ara h 6 mono-sensitisation has been neglected in literature. We present a case series of five children with sensitisation to peanut component Ara h 6. Only one of these five patients showed Ara h 8 cosensitivity. Three out of the five children had a positive double-blind placebo-controlled food challenge (DBPCFC), with moderate to strong reactions.

Conclusion: A mono-sensitisation to peanut component Ara h 6 is uncommon but can cause severe allergic reactions. Therefore, the determination of sIgE to Ara h 6 is warranted in patients with a suspected peanut allergy, especially in the absence of sensitisation to Ara h 1, 2, 3 and 9.

What is known: • Peanut allergy is common and can cause severe allergic reactions. • The diagnostics of peanut allergy has recently improved with the use of component resolved diagnosis What is new: • A mono-sensitisation to peanut component Ara h 6 is uncommon, but can cause severe allergic reactions • Determination of sIgE to Ara h 6 is warranted in patients with a suspected peanut allergy, especially in the absence of sensitisation to Ara h 1, 2, 3 and 9.

Keywords: Ara h 6; Components; Double-blind placebo-controlled food challenge (DBPCFC); Peanut allergy.

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Conflict of interest statement

Compliance with ethical standards This study was not funded. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Conflict of interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Summary of the search and selection
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