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Review
. 2016 Nov;20(6):509-516.
doi: 10.1177/1203475416651605. Epub 2016 May 20.

The Role of IL-17 in the Pathogenesis of Psoriasis and Update on IL-17 Inhibitors for the Treatment of Plaque Psoriasis

Mohn'd AbuHilal  1 , Scott Walsh  2 , Neil Shear  2
Affiliations
Review

The Role of IL-17 in the Pathogenesis of Psoriasis and Update on IL-17 Inhibitors for the Treatment of Plaque Psoriasis

Mohn'd AbuHilal et al. J Cutan Med Surg. 2016 Nov.

Abstract

Background: Major advances have been made in the understanding of the pathophysiology of psoriasis.

Objectives: The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor.

Methods: A PubMed search was performed for relevant literature.

Conclusion: The IL-23/Th17 signaling pathway (including IL-17) plays a central role in the pathogenesis of psoriasis. Biologic agents that block IL-17 (secukinumab and ixekizumab) or its receptor (brodalumab) are effective and safe for the treatment of psoriasis.

Keywords: IL-17; brodalumab; ixekizumab; psoriasis; secukinumab.

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