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Randomized Controlled Trial
. 2016 Aug 12;19(8):pyw025.
doi: 10.1093/ijnp/pyw025. Print 2016 Aug.

Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial

Antoine Pelissolo  1 , Ghina Harika-Germaneau  2 , Fady Rachid  2 , Christian Gaudeau-Bosma  2 , Marie-Laure Tanguy  2 , Rene BenAdhira  2 , Noomane Bouaziz  2 , Traian Popa  2 , Issa Wassouf  2 , Ghassen Saba  2 , Dominique Januel  2 , Nematollah Jaafari  2
Affiliations
Randomized Controlled Trial

Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial

Antoine Pelissolo et al. Int J Neuropsychopharmacol. .

Abstract

Background: Repetitive transcranial magnetic stimulation has been explored in patients with obsessive-compulsive disorder, but with negative or conflicting results. This randomized double-blind study was designed to assess the efficacy of 1-Hz repetitive transcranial magnetic stimulation over the presupplementary area.

Methods: Forty medication-resistant patients were assigned to 4 weeks of either active or sham repetitive transcranial magnetic stimulation targeting the presupplementary area with the help of a neuronavigation system.

Results: According to the Yale-Brown obsessive-compulsive scale, the baseline-week 4 evolution showed no significant differences between groups. Responder rates at week 4 were not different between groups (repetitive transcranial magnetic stimulation 10.5% vs sham 20%; P=.63).

Conclusion: Low-frequency repetitive transcranial magnetic stimulation applied to the presupplementary area seems ineffective for the treatment of obsessive-compulsive disorder patients, at least in severe and drug-refractory cases such as those included in this study. Further research is required to determine profiles of responder patients and appropriate repetitive transcranial magnetic stimulation parameters for obsessive-compulsive disorder.

Keywords: SMA; obsessive-compulsive disorder; repetitive transcranial magnetic stimulation; treatment.

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Figure 1.
Flow-chart of the study.
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