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. 2016 Aug:127:10-12.
doi: 10.1016/j.mimet.2016.05.016. Epub 2016 May 18.

A new method for long-term storage of titred microbial standard solutions suitable for microbiologic quality control activities of pharmaceutical companies

Carolina Chiellini  1 , Stefano Mocali  2 , Renato Fani  3 , Iolanda Ferro  4 , Serenella Bruschi  5 , Alessandro Pinzani  4
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A new method for long-term storage of titred microbial standard solutions suitable for microbiologic quality control activities of pharmaceutical companies

Carolina Chiellini et al. J Microbiol Methods. 2016 Aug.

Abstract

Commercially available lyophilized microbial standards are expensive and subject to reduction in cell viability due to freeze-drying stress. Here we introduce an inexpensive and straightforward method for in-house microbial standard preparation and cryoconservation that preserves constant cell titre and cell viability over 14 months.

Keywords: Cryopreservation; Pharmacopoeia; Standard reference strains.

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