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Review
. 2016 Jun;30(2):391-414.
doi: 10.1016/j.idc.2016.02.005.

Agents of Last Resort: Polymyxin Resistance

Keith S Kaye  1 , Jason M Pogue  2 , Thien B Tran  3 , Roger L Nation  3 , Jian Li  3
Affiliations
Review

Agents of Last Resort: Polymyxin Resistance

Keith S Kaye et al. Infect Dis Clin North Am. 2016 Jun.

Abstract

Polymyxin resistance is a major public health threat, as the polymyxins represent "last-line" therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

Keywords: Colistin; Gram-negative; Polymyxin B; Polymyxins; Resistance.

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