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Review
. 2016 Jun;30(2):509-522.
doi: 10.1016/j.idc.2016.02.010.

Drug-Resistant Tuberculosis: Challenges and Progress

Sebastian G Kurz  1 , Jennifer J Furin  2 , Charles M Bark  3
Affiliations
Review

Drug-Resistant Tuberculosis: Challenges and Progress

Sebastian G Kurz et al. Infect Dis Clin North Am. 2016 Jun.

Abstract

Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited resources, poverty, and neglect have led to the emergence of drug-resistant tuberculosis throughout the world. The international community has responded with financial and scientific support, leading to new rapid diagnostics, new drugs and regimens in advanced clinical development, and an increasingly sophisticated understanding of resistance mechanisms and their application to all aspects of TB control and treatment.

Keywords: Antimicrobial resistance; Drug-resistant tuberculosis; Mycobacterium tuberculosis.

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References

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