What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry
- PMID: 27210023
- PMCID: PMC4983226
- DOI: 10.1053/j.semperi.2016.03.003
What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry
Abstract
The cesarean delivery rate in the United States has risen steadily over the past 5 decades such that approximately one in three women now undergo cesarean section. The rise in repeat operations and accompanying decline in trial of labor after cesarean (TOLAC) have been major contributors to this phenomenon. The appropriate use of TOLAC continues to be a topic of interest with the recognition that most women with a history of prior cesarean are candidates for trial of labor. The NICHD MFMU Network Cesarean Registry conducted from 1999 to 2002 provided contemporary data concerning the risks and benefits of TOLAC, which in turn have helped inform practitioners and women considering their options for childbirth following cesarean delivery.
Keywords: TOLAC; Uterine Rupture; VBAC.
Copyright © 2016 Elsevier Inc. All rights reserved.
Figures

Similar articles
-
Delivery for women with a previous cesarean: guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF).Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):25-32. doi: 10.1016/j.ejogrb.2013.05.015. Epub 2013 Jun 28. Eur J Obstet Gynecol Reprod Biol. 2013. PMID: 23810846 Review.
-
Trial of Labor After Cesarean Delivery in Individuals With Twin Pregnancies and Two Prior Cesarean Deliveries.Obstet Gynecol. 2025 Mar 1;145(3):325-334. doi: 10.1097/AOG.0000000000005830. Epub 2025 Jan 16. Obstet Gynecol. 2025. PMID: 39820347
-
Vaginal birth after cesarean section: Experience from a regional hospital.Taiwan J Obstet Gynecol. 2022 May;61(3):422-426. doi: 10.1016/j.tjog.2022.03.006. Taiwan J Obstet Gynecol. 2022. PMID: 35595432
-
Oxytocin use in trial of labor after cesarean and its relationship with risk of uterine rupture in women with one previous cesarean section: a meta-analysis of observational studies.BMC Pregnancy Childbirth. 2021 Jan 6;21(1):11. doi: 10.1186/s12884-020-03440-7. BMC Pregnancy Childbirth. 2021. PMID: 33407241 Free PMC article.
-
Vaginal birth after cesarean: an effective method to reduce cesarean.Clin Obstet Gynecol. 2015 Jun;58(2):309-19. doi: 10.1097/GRF.0000000000000101. Clin Obstet Gynecol. 2015. PMID: 25811124 Review.
Cited by
-
[Vaginal birth after previous cesarean section in low-resource countries: healthcare chain and materno-fetal follow-up].Pan Afr Med J. 2018 Aug 6;30:255. doi: 10.11604/pamj.2018.30.255.15678. eCollection 2018. Pan Afr Med J. 2018. PMID: 30637040 Free PMC article. French.
-
Outcomes of trial of labor after cesarean birth by provider type in low-risk women.Birth. 2020 Mar;47(1):123-134. doi: 10.1111/birt.12474. Epub 2019 Dec 10. Birth. 2020. PMID: 31823421 Free PMC article.
-
Mechanical Methods for the Induction of Labour After Previous Caesarean Section - An Updated, Evidence-based Review.Geburtshilfe Frauenheilkd. 2022 Mar 16;82(7):727-735. doi: 10.1055/a-1731-7441. eCollection 2022 Jul. Geburtshilfe Frauenheilkd. 2022. PMID: 35815098 Free PMC article.
-
Vaginal birth after cesarean section and its associated factors in Ethiopia: a systematic review and meta-analysis.Sci Rep. 2023 May 15;13(1):7882. doi: 10.1038/s41598-023-34856-8. Sci Rep. 2023. PMID: 37188702 Free PMC article.
-
Risk Factors Associated with Uterine Rupture and Dehiscence: A Cross-Sectional Canadian Study.Rev Bras Ginecol Obstet. 2021 Nov;43(11):820-825. doi: 10.1055/s-0041-1739461. Epub 2021 Dec 6. Rev Bras Ginecol Obstet. 2021. PMID: 34872139 Free PMC article.
References
-
- Landon MB, Hauth JC, Leveno KJ, Spong CY, et al. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery. N Engl J Med 16. 2004;351(25):2581–2589. - PubMed
-
- Landon MB, Leindecker S, Spong CY, et al. for the NICHD Maternal-Fetal Medicine Units Network. The MFMU Cesarean Registry: Factors affecting the success and trial of labor following prior cesarean delivery. Am J of Obstet Gynecol. 2005;193(3):1016–1023. - PubMed
-
- Mercer BM, Gilbert S, Landon MB, Spong CY, et al. the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Labor outcomes with increasing number of prior vaginal births after cesarean delivery. Obstet Gynecol. 2008;111(2 Pt 1):285–291. - PubMed
-
- Grobman WA, Lai Y, Landon MB, Spong CY, et al. the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prediction of uterine rupture associated with attempted vaginal birth after cesarean delivery. Am J Obstet Gynecol. 2008;199(1):30.e1–35.e1. - PMC - PubMed
-
- Landon MB, Spong CY, Thom E, Hauth JC, et al. the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery. Obstet Gynecol. 2006;108(1):12–20. - PubMed
Publication types
MeSH terms
Grants and funding
- U10 HD040500/HD/NICHD NIH HHS/United States
- U10 HD040544/HD/NICHD NIH HHS/United States
- UG1 HD034116/HD/NICHD NIH HHS/United States
- UG1 HD040560/HD/NICHD NIH HHS/United States
- U10 HD034136/HD/NICHD NIH HHS/United States
- UG1 HD027915/HD/NICHD NIH HHS/United States
- U10 HD040485/HD/NICHD NIH HHS/United States
- U10 HD027905/HD/NICHD NIH HHS/United States
- U10 HD034116/HD/NICHD NIH HHS/United States
- U10 HD027869/HD/NICHD NIH HHS/United States
- U10 HD040560/HD/NICHD NIH HHS/United States
- U10 HD034208/HD/NICHD NIH HHS/United States
- UG1 HD040500/HD/NICHD NIH HHS/United States
- U10 HD040512/HD/NICHD NIH HHS/United States
- U10 HD040545/HD/NICHD NIH HHS/United States
- U01 HD036801/HD/NICHD NIH HHS/United States
- UG1 HD027869/HD/NICHD NIH HHS/United States
- M01 RR000034/RR/NCRR NIH HHS/United States
- UG1 HD040544/HD/NICHD NIH HHS/United States
- UG1 HD034208/HD/NICHD NIH HHS/United States
- UG1 HD040512/HD/NICHD NIH HHS/United States
- U10 HD027917/HD/NICHD NIH HHS/United States
- U10 HD034122/HD/NICHD NIH HHS/United States
- U10 HD027915/HD/NICHD NIH HHS/United States
- UG1 HD040545/HD/NICHD NIH HHS/United States
- UG1 HD040485/HD/NICHD NIH HHS/United States
- U10 HD027860/HD/NICHD NIH HHS/United States
- U10 HD021410/HD/NICHD NIH HHS/United States
- U10 HD036801/HD/NICHD NIH HHS/United States
- U24 HD036801/HD/NICHD NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous