The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans
- PMID: 27210436
- DOI: 10.1016/j.bmcl.2016.05.013
The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans
Abstract
To identify effective and low toxicity synergistic antifungal compounds, 24 derivatives of chalcone were synthesized to restore the effectiveness of fluconazole against fluconazole-resistant Candida albicans. The minimal inhibitory concentration (MIC80) and the fractional inhibitory concentration index (FICI) of the antifungal synergist fluconazole were measured against fluconazole-resistant Candida albicans. This was done via methods established by the clinical and laboratory standards institute (CLSI). Of the synthesized compounds, 2'-hydroxy-4'-methoxychalcone (8) exhibited the most potent in vitro (FICI=0.007) effects. The structure activity relationship of the compounds are then discussed.
Keywords: Antifungal effect; Candida albicans; Chalcone; Fluconazole; Synergist.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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