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. 2016 Apr;11(4):575-7.
doi: 10.4103/1673-5374.180741.

Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury

Chia-Chi Liao  1 , Jamie L Reed  1 , Hui-Xin Qi  1
Affiliations

Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury

Chia-Chi Liao et al. Neural Regen Res. 2016 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Summary diagram depicting how the extent of dorsal column lesion (DCL) in the cervical spinal cord altered the ascending inputs from the hand and face to the brainstem, thalamus, primary somatosensory area 3b, and the intracortical connections of the hand region in area 3b. The hand pathway from normal, incomplete DCL, and complete DCL monkeys are in shown blue, light blue, and red, respectively, and the face pathway is shown in green. In the cortex, territories of the hand, forelimb, and face regions in the cortex are shown in dark to light gray, and the thickness of each line represents the relative density of the connection. Note, along with the existing connections from the hand region of areas 3a, 1, 2, and PV/S2 and other cortical areas as in normal monkeys, after long-term DCL the hand region in area 3b is additionally connected to the face region in area 3b (asterisks in Cortex). However, sprouting of the face inputs into the hand region of brainstem (cuneate nucleus, Cu) only appears in monkeys with the complete DCL (asterisks in Brainstem). The thalamocortical connections of the hand and face inputs remain somatotopically organized after the DCL. LS: Lateral sulcus; M1: primary motor cortex; PMd and PMv: premotor dorsal and ventral cortex; PR: parietal rostral; PV: parietal ventral; Ri: retroinsular cortex; S2: secondary somatosensory cortex.
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