Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;11(4):575-7.
doi: 10.4103/1673-5374.180741.

Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury

Chia-Chi Liao  1 , Jamie L Reed  1 , Hui-Xin Qi  1
Affiliations

Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury

Chia-Chi Liao et al. Neural Regen Res. 2016 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Summary diagram depicting how the extent of dorsal column lesion (DCL) in the cervical spinal cord altered the ascending inputs from the hand and face to the brainstem, thalamus, primary somatosensory area 3b, and the intracortical connections of the hand region in area 3b. The hand pathway from normal, incomplete DCL, and complete DCL monkeys are in shown blue, light blue, and red, respectively, and the face pathway is shown in green. In the cortex, territories of the hand, forelimb, and face regions in the cortex are shown in dark to light gray, and the thickness of each line represents the relative density of the connection. Note, along with the existing connections from the hand region of areas 3a, 1, 2, and PV/S2 and other cortical areas as in normal monkeys, after long-term DCL the hand region in area 3b is additionally connected to the face region in area 3b (asterisks in Cortex). However, sprouting of the face inputs into the hand region of brainstem (cuneate nucleus, Cu) only appears in monkeys with the complete DCL (asterisks in Brainstem). The thalamocortical connections of the hand and face inputs remain somatotopically organized after the DCL. LS: Lateral sulcus; M1: primary motor cortex; PMd and PMv: premotor dorsal and ventral cortex; PR: parietal rostral; PV: parietal ventral; Ri: retroinsular cortex; S2: secondary somatosensory cortex.
See this image and copyright information in PMC

References

    1. Burton H, Fabri M. Ipsilateral intracortical connections of physiologically defined cutaneous representations in areas 3b and 1 of macaque monkeys: projections in the vicinity of the central sulcus. J Comp Neurol. 1995;355:508–538. - PubMed
    1. Chand P, Jain N. Intracortical and thalamocortical connections of the hand and face representations in somatosensory area 3b of macaque monkeys and effects of chronic spinal cord injuries. J Neurosci. 2015;35:13475–13486. - PMC - PubMed
    1. Darian-Smith C, Lilak A, Garner J, Irvine KA. Corticospinal sprouting differs according to spinal injury location and cortical origin in macaque monkeys. J Neurosci. 2014;34:12267–12279. - PMC - PubMed
    1. Kambi N, Halder P, Rajan R, Arora V, Chand P, Arora M, Jain N. Large-scale reorganization of the somatosensory cortex following spinal cord injuries is due to brainstem plasticity. Nat Commun. 2014;5:3602. - PubMed
    1. Li CX, Chappell TD, Ramshur JT, Waters RS. Forelimb amputation-induced reorganization in the ventral posterior lateral nucleus (VPL) provides a substrate for large-scale cortical reorganization in rat forepaw barrel subfield (FBS) Brain Res. 2014;1583:89–108. - PMC - PubMed