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Review
. 2016 May 20;8(5):310.
doi: 10.3390/nu8050310.

The Possible Role of Flavonoids in the Prevention of Diabetic Complications

Roberto Testa  1 , Anna Rita Bonfigli  2 , Stefano Genovese  3 , Valeria De Nigris  4 , Antonio Ceriello  5   6   7
Affiliations
Review

The Possible Role of Flavonoids in the Prevention of Diabetic Complications

Roberto Testa et al. Nutrients. .

Abstract

Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.

Keywords: diabetic complications; flavonoids; type 2 diabetes mellitus.

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Figures

Figure 1
Figure 1
Basic chemical structure of a flavonoid.
See this image and copyright information in PMC

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