Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Jul;151(1):9-12.
doi: 10.1053/j.gastro.2016.05.009. Epub 2016 May 20.

The Toronto Helicobacter pylori Consensus in Context

David Y Graham  1 , Loren Laine  2
Affiliations
Editorial

The Toronto Helicobacter pylori Consensus in Context

David Y Graham et al. Gastroenterology. 2016 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

The authors have made the following disclosures: Dr Graham is a consultant for RedHill Biopharma regarding novel Helicobacter pylori therapies and has received research support for culture of H pylori and is the principal investigator of an international study of the use of antimycobacterial therapy for Crohn’s disease. He is also a consultant for BioGaia in relation to probiotic therapy for H pylori infection. Dr Laine has nothing to declare.

Figures

Figure 1.
Figure 1.
Helicobacter pylori eradication rates with proton pump inhibitor triple therapy in populations with varying proportions of clarithromycin resistance. Based on a theoretical population where the cure rate is 95% with susceptible infections and 15% with resistant infections.
Figure 2.
Figure 2.
Example of one possible set of recommendations for susceptibility-based first-line Helicobacter pylori therapy. This example is based on the premises that it is preferable to minimize the use of unnecessary antibiotics and that proton pump inhibitors, amoxicillin, and third drug triple therapies are usually better tolerated than bismuth quadruple therapy.
See this image and copyright information in PMC

Comment on

References

    1. Institute of Medicine. Clinical practice guidelines we can trust. Washington, DC: The National Academies Press, 2011.
    1. Fallone CA, Chiba N, van Zanten SV, et al. The Toronto consensus for the treatment of Helicobacter pylori infection in adults. Gastroenterology 2016;151:51–69. - PubMed
    1. Wenzhen Y, Yumin L, Quanlin G, et al. Is antimicrobial susceptibility testing necessary before first-line treatment for Helicobacter pylori infection? Meta-analysis of randomized controlled trials. Intern Med 2010;49:1103–1109. - PubMed
    1. Graham DY, Dore MP. Helicobacter pylori therapy: a paradigm shift. Expert Rev Anti Infect Ther 2016. May 3 [Epub ahead of print]. - PMC - PubMed
    1. Graham DY, Lee YC, Wu MS. Rational Helicobacter pylori therapy: evidence-based medicine rather than medicine-based evidence. Clin Gastroenterol Hepatol 2014;12:177–186. - PMC - PubMed

LinkOut - more resources