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. 2016 Jul 22;60(8):5033-5.
doi: 10.1128/AAC.00440-16. Print 2016 Aug.

Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China

Hua Yu  1 , Fen Qu  2 , Bin Shan  3 , Bin Huang  4 , Wei Jia  5 , Cha Chen  6 , Aiqing Li  7 , Minhui Miao  7 , Xin Zhang  1 , Chunmei Bao  2 , Yunmin Xu  3 , Kalyan D Chavda  8 , Yi-Wei Tang  9 , Barry N Kreiswirth  8 , Hong Du  10 , Liang Chen  11
Affiliations

Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China

Hua Yu et al. Antimicrob Agents Chemother. .

Abstract

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

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Figures

FIG 1
FIG 1
Chromosomal integration of mcr-1 gene. Arrows denote open reading frames (ORF), with red, gray, yellow, and white arrows denoting mcr-1, pap2, ISApl1, and neighboring chromosomal genes (illustrated by locus_tag in ST156 strain SE11 [GenBank accession no. AP009240]), respectively. The small black arrows adjacent to ISApl1 denote the inverted reverse repeats (IRR). The 2-bp putative target duplicated sequences for TnApl1 are underlined.
See this image and copyright information in PMC

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