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. 1989 May 8;248(1-2):101-4.
doi: 10.1016/0014-5793(89)80440-5.

Immunological evidence for the role of phosphoprotein p68/pI = 7.3 in premessenger RNA splicing

C C Liew  1 , H C Smith
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Free article

Immunological evidence for the role of phosphoprotein p68/pI = 7.3 in premessenger RNA splicing

C C Liew et al. FEBS Lett. .
Free article

Abstract

A 68 kDa (pI = 7.3) nuclear phosphoprotein has been previously characterized as a component of transcriptionally active chromatin. Two-dimensional PAGE Western blotting and radioimmunoassay with monoclonal antibodies have identified this protein in nuclear extracts used for in vitro RNA splicing. In vitro splicing activity could be quantitatively inhibited by preincubating nuclear extracts with the antibodies, but the assembly of 60 S spliceosomes could not.

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