Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Jul 1;111(1):1-4.
doi: 10.1093/cvr/cvw110. Epub 2016 May 23.

Pulmonary hypertension begets pulmonary hypertension: mutually reinforcing roles for haemodynamics, inflammation, and cancer-like phenotypes

Affiliations
Editorial

Pulmonary hypertension begets pulmonary hypertension: mutually reinforcing roles for haemodynamics, inflammation, and cancer-like phenotypes

Danchen Wu et al. Cardiovasc Res. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A mechanistic figure proposing integration of the role of pulmonary hypertension in progression of vascular disease in PAH as reported in the study by Abe et al., with the neoplastic paradigm of PAH pathogenesis. PA, pulmonary artery; PVR, pulmonary vascular resistance; RV, right ventricle; IL-1ra, interleukin-l receptor antagonist; LPAB, left pulmonary artery banding.

Comment on

References

    1. Archer SL, Weir EK, Wilkins MR. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 2010;121:2045–2066. - PMC - PubMed
    1. Archer SL. Mitochondrial dynamics—mitochondrial fission and fusion in human diseases. N Engl J Med 2013;369:2236–2251. - PubMed
    1. Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, Patterson AJ, Agrawal R, Rabinovitch M, Ambler K, Long CS, Voelkel NF, Nicolls MR. Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res 2011;109:867–879. - PMC - PubMed
    1. Ormiston ML, Chang C, Long LL, Soon E, Jones D, Machado R, Treacy C, Toshner MR, Campbell K, Riding A, Southwood M, Pepke-Zaba J, Exley A, Trembath RC, Colucci F, Wills M, Trowsdale J, Morrell NW. Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension. Circulation 2012;126:1099–1109. - PubMed
    1. Dasgupta A, Bowman L, D'Arsigny CL, Archer SL. Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Clin Pharmacol Ther 2015;97:88–102. - PMC - PubMed