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. 2016 Jul-Aug;45(7-8 Pt 1):631-7.
doi: 10.1016/j.lpm.2016.04.016. Epub 2016 May 20.

[Pathophysiology of preeclampsia]

[Article in French]
Edouard Lecarpentier  1 , Thierry Fournier  2 , Jean Guibourdenche  1 , Vassilis Tsatsaris  3
Affiliations

[Pathophysiology of preeclampsia]

[Article in French]
Edouard Lecarpentier et al. Presse Med. 2016 Jul-Aug.

Abstract

Preeclampsia is a hypertensive disease of pregnancy due to abnormal utero-placental circulation. Hypoperfusion of the placenta and hypoxia/reoxygenation of the intervillous space are responsible of placental dysfunction. Trophoblastic factors are released in the maternal circulation and are responsible of the maternal endothelial dysfunction that characterize preeclampsia. Among those factors, the PlGF/sFlt-1 couple plays a major pathophysiologic role.

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