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Review
. 2016 Oct;28(7):563-575.
doi: 10.1177/1010539516650722. Epub 2016 Jul 10.

Meta-Analysis of the Association Between Whole and Refined Grain Consumption and Stroke Risk Based on Prospective Cohort Studies

Jianguo Chen  1   2 , Qingfeng Huang  2 , Wei Shi  2 , Liu Yang  2 , Jian Chen  2 , Qing Lan  1
Affiliations
Review

Meta-Analysis of the Association Between Whole and Refined Grain Consumption and Stroke Risk Based on Prospective Cohort Studies

Jianguo Chen et al. Asia Pac J Public Health. 2016 Oct.

Abstract

The association between whole and refined grain consumption and stroke risk remains unclear. A search using MEDLINE and EMBASE databases was performed through February 29, 2016. Seven prospective studies with a total of 446 451 subjects and 5892 stroke events were included. The summary relative risk (SRR) of stroke for the high versus low consumption was 0.95 (95% confidence interval [CI] = 0.83-1.14) for total grains, 0.92 (95% CI = 0.72-1.17) for whole grains, and 0.99 (95% CI = 0.84-1.16) for refined grains. Diets rich in whole grains were inversely associated with ischemic stroke risk (SRR = 0.75, 95% CI = 0.60-0.95). Our meta-analysis revealed that whole and refined grain consumption is not associated with total stroke risk; however, whole grain consumption is associated with reduced ischemic stroke risk.

Keywords: meta-analysis; refined grains; relative risk; stroke; whole grains.

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