Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May-Jun;24(3):131-6.
doi: 10.1590/1413-785220162403149200.

EFFECT OF TRANEXAMIC ACID ON BLEEDING CONTROL IN TOTAL KNEE ARTHROPLASTY

David Sadigursky  1 , Daniel Andion  1 , Péricles Boureau  1 , Maria Cordulina Ferreira  1 , Rogério Jamil Fernandes Carneiro  1 , Paulo Oliveira Colavolpe  1
Affiliations

EFFECT OF TRANEXAMIC ACID ON BLEEDING CONTROL IN TOTAL KNEE ARTHROPLASTY

David Sadigursky et al. Acta Ortop Bras. 2016 May-Jun.

Abstract

Objectives: To analyze the effectiveness of intravenous (IV) tranexamic acid (TA) in reducing blood loss in total knee arthroplasty (TKA).

Method: The population sample was composed of patients with a diagnosis of primary knee osteoarthritis. The patients undergoing TKA were divided in two groups. Group A: comprised patients who used IV TA and B group, formed by patients who did not use TA in the intra or post-operative period. For descriptive analysis, quantitative variables were represented by mean and standard deviations when their distribution was normal and interquartile ranges and medians for non-normal variables.

Results: The mean age of patients was 68 years old, most of them were female and with involvement of the left knee. Postoperatively patients who had used IV TA showed less bleeding rate and less hemoglobin rate reduction.

Conclusion: The use of IV TA in TKA reduces blood loss in peri- and postoperative periods. Regarding total blood loss reduction, hemoglobin rate and need for blood transfusions, IV TA should be used routinely during TKA since it has been shown to be safe with no increase in side effects as thromboembolic events. Level of Evidence III. Retrospective Comparative Study.

Keywords: Artrhoplasty, replacement, knee; Hemorrhage; Knee; Tranexamic acid.

PubMed Disclaimer

Conflict of interest statement

All the authors declare that there is no potential conflict of interest referring to this article.

Figures

Figure 1
Figure 1. Gender frequency by group.
Figure 2
Figure 2. Age by group.
Figure 3
Figure 3. Comorbidities per group.
Figure 4
Figure 4. Transfusion per group.
Figure 5
Figure 5. Blood loss per group.
Figure 6
Figure 6. Hemoglobin per time and group.
Figure 7
Figure 7. Boxplot: Hemoglobin 48h postoperative.
See this image and copyright information in PMC

References

    1. Kakar PN, Gupta N, Govil P, Shah V. Efficacy and safety of tranexamic acid in control of bleeding following TKR a randomized clinical trial. Indian J Anaesth. 2009;53(6):667–671. - PMC - PubMed
    1. Karam JA, Bloomfield MR, DiIorio TM, Irizarry AM, Sharkey PF. Evaluation of the efficacy and safety of tranexamic acid for reducing blood loss in bilateraltotal knee arthroplasty. J Arthroplasty. 2014;29(3):501–503. - PubMed
    1. Camarasa MA, Ollé G, Serra-Prat M, Martín A, Sánchez M, Ricós P. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement a randomized clinical trial. Br J Anaesth. 2006;96(5):576–582. - PubMed
    1. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br. 2001;83(5):702–705. - PubMed
    1. Wind TC, Barfield WR, Moskal JT. The effect of tranexamic acid on blood loss and transfusion rate in primary total knee arthroplasty. J Arthroplasty. 2013;28(7):1080–1083. - PubMed

LinkOut - more resources