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. 2016 May-Jun;24(3):142-6.
doi: 10.1590/1413-785220162403157033.

SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA

Juan Pablo Zumárraga  1 , André Mathias Baptista  1 , Luis Pablo De La Rosa  1 , Marcelo Tadeu Caiero  1 , Olavo Pires De Camargo  1
Affiliations

SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA

Juan Pablo Zumárraga et al. Acta Ortop Bras. 2016 May-Jun.

Abstract

Objective: To study the relationship between the pre and post chemotherapy (CT) serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) found in specimens after the pre surgical CT in patients with osteosarcoma.

Methods: Series of cases with retrospective evaluation of patients diagnosed with osteosarcoma. Participants were divided into two groups according to serum values of both enzymes. The values of AP and LDH were obtained before and after preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens of each patient was also included.

Results: One hundred and thirty seven medical records were included from 1990 to 2013. Both the AP as LDH decreased in the patients studied, being the higher in pre CT than post CT. The average LHD decrease was 795.12U/L and AP decrease was 437.40 U/L. The average TN was 34.10 %. There was no statistically significant correlation between the serums values and the percentage of tumoral necrosis.

Conclusion: The serum levels values of AP and LDH are not good predictors for the chemotherapy-induced necrosis in patients with osteosarcoma. Level of Evidence IV, Case Series.

Keywords: Alkaline phosphatase; Drug therapy; L-Lactate Dehydrogenase; Osteosarcoma; Prognosis.; Tumor necrosis factors.

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Conflict of interest statement

All the authors declare that there is no potential conflict of interest referring to this article.

Figures

Figure 1
Figure 1. Dispersion diagram of AP pre- and post-chemotherapy.
Figure 2
Figure 2. Dispersion diagram of LDH pre- and post-chemotherapy.
Figure 3
Figure 3. Dispersion diagram of LDH and AP pre-chemotherapy.
Figure 4
Figure 4. Dispersion diagram of LDH and AP post-chemotherapy.
Figure 5
Figure 5. Dispersion diagram of percentage of necrosis and AP pre- and post chemotherapy.
Figure 6
Figure 6. Dispersion diagram of percentage of necrosis and LDH pre- and post chemotherapy.
See this image and copyright information in PMC

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