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. 2016 Feb 6;21(1):e19676.
doi: 10.5812/traumamon.19676. eCollection 2016 Feb.

Effective Factors in Door-to-Needle Time for Streptokinase Administration in Patients With Acute Myocardial Infarction Admitted to the Emergency Department

Ali Omraninava  1 , Amir Masoud Hashemian  2 , Babak Masoumi  3
Affiliations

Effective Factors in Door-to-Needle Time for Streptokinase Administration in Patients With Acute Myocardial Infarction Admitted to the Emergency Department

Ali Omraninava et al. Trauma Mon. .

Abstract

Background: Cardiovascular incidents are a common cause of death around the world. Acute myocardial infarction (AMI) poses high risks for the patient due to plaque rupture or erosion along with a superimposed non-occlusive thrombus; therefore, timely treatment with antithrombotic agents plays a key role in reducing an AMI mortality rate.

Objectives: The present study aimed to assess the time interval between the admission of AMI-suspected patients and treatment initiation.

Patients and methods: This cross-sectional study was conducted on 110 patients admitted to the emergency department of Imam Hussein hospital in Tehran, Iran. Data were collected using checklists, completed by the patients' next of kin or the emergency staff. To analyze the data, student t- test and analysis of variance were used.

Results: In this study, 31 female and 79 male subjects were included, respectively. The mean time to receive the first dose of streptokinase was 66.39 minutes (73.74 minutes for females and 63.5 minutes for male patients), varying from 49.92 minutes in the morning to 69.78 minutes in the afternoon and 72.68 minutes during night shifts.

Conclusions: The door-to-needle (DTN) time, in a standard setting, is recommended to be less than 30 minutes. According to the results of this study, the DTN time is comparatively two times longer in females and afternoon and night shifts. Different variables including emergency staff, physicians, patients' characteristics, and environmental/physical factors induced this difference.

Keywords: Acute Myocardial Infarction; Emergency Service; Needle Stick Injuries; Streptokinase.

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Figures

Figure 1.
Figure 1.. Diagram of Distribution of Admission of the Patients in Various Working Shifts
Figure 2.
Figure 2.. The Correlation Between Age and Door-to-Needle Time in Patients
Figure 3.
Figure 3.. The Correlation Between Age and Time to Onset of Chest Pain Until Admission in the Emergency Department
Figure 4.
Figure 4.. The Correlation Between Age and Time of Electrocardiography to Thrombolytic Therapy.
See this image and copyright information in PMC

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